Intracellular calcium signaling.
نویسندگان
چکیده
In excitable cells, the major pathway for Ca2+ influx is via highly Ca2+-selective voltage-gated Ca2+ channels (VGCC). The original alphabetical nomenclature was replaced recently with standard numerical nomenclature: Cav1.1-1.4, Cav2.1-2.3, Cav3.1-3.3. In skeletal muscle cells, an additional voltagesensitive pathway is provided by dihydropyridine receptors (DHPR, Cav1.1) that do not pass significant amounts of Ca2+ but are physically coupled to ryanodine receptor channels (RyR) on the sarcoand endoplasmic reticulum (ER) membrane. Indirectly, voltage also modulates the amount of Ca2+ entry through all voltageindependent Ca2+ channels by modifying the driving force for Ca2+ influx, with more entry at hyperpolarized potentials.
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عنوان ژورنال:
- Journal of cell science
دوره 115 Pt 19 شماره
صفحات -
تاریخ انتشار 2002